The American Academy of Pediatrics recommendation to refrain from rectal acetaminophen in children should possibly be revised. Rectal and oral acetaminophen are comparable with respect to temperature reduction. We did not perform a meta-analysis comparing rectal and oral acetaminophen for pain reduction because only 1 study fulfilled the inclusion criteria. 99), or the average time to temperature reduction of 1 degrees C (WMD, -0.06 degrees C 95% CI, -1.34 degrees C to 1.23 degrees C P <. 84), the maximum decline in temperature (WMD, -0.10 degrees C 95% CI, -0.24 degrees C to 0.04 degrees C P >. There was no difference in the decline of temperature 3 hours after administration (WMD, -0.10 degrees C 95% CI, -0.41 degrees C to 0.21 degrees C P =. Carefully follow the label instructions for the maximum dose per day. The decline in temperature 1 hour after administration of acetaminophen was no different between rectal and oral administration (weighted mean difference, -0.14 degrees C 95% confidence interval, -0.36 degrees C to 0.08 degrees C P for heterogeneity =. For pain or fever: For oral and rectal dosage forms (capsules, granules, powders, solution, suppositories, suspension, or tablets): Adults and teenagers650 to 1000 milligrams (mg) every 4 to 6 hours as needed. Standardized measures of temperature and pain reduction.įor temperature reduction, 4 studies met the inclusion criteria. Main Exposure Oral vs rectal acetaminophen. Reviews, letters, and studies that compared combined treatments or additional drugs were excluded. Randomized and quasi-randomized controlled studies comparing rectal and oral administration of acetaminophen were included. MEDLINE, PubMed, and the Cochrane database as well as major pharmacologic textbooks and the references of all included studies were searched for studies comparing oral and rectal administration of acetaminophen. 2000 320:11741178.Rectal temperature is considered the gold standard by many and outcome studies have often used rectal temperature to make clinical decisions. 21 A simple conversion between surface and internal temperature 18,20 would be useful for clinical care and research in KD. even with an axillary threshold of 37.2☌. ![]() Age affects your ability to regulate body temperature. Tympanic (ear) temps are accurate, but more variable than oral or rectal. Temps taken rectally are 0.7° F (0.4° C) higher than those taken orally. Lowest temperature occurs around 6 am and highest between 4 and 6 pm. To determine, on the basis of published studies, the efficacy of rectal vs oral acetaminophen as treatment of fever and pain. Axillary thresholds of 37.5☌ and 37.2☌ provided maximal sensitivity and specificity to detect oral and rectal temperatures 38.0☌. Your temperature can vary about 1° F (0.5° C) during the day.
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